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Original Article
Evaluation of Anthelmintic Activity of Caesalpinia Pulcherrima Leaf Extract by In-Silico and In-Vitro Studies
Indrapati Mamatha1
Saadana Yekkaldev2
Sk. Sushma Taj3
1Assistant Professor, department of pharmaceutical chemistry, Joginpally B.R. Pharmacy College, Hyderabad, Telangana, India. 2Student, Joginpally B.R. Pharmacy College, Hyderabad, Telangana, India. 3Assistant Professor, department of pharmaceutics, Joginpally B.R. Pharmacy College, Hyderabad, Telangana, India.
Published Online: January-February 2024
Pages: 36-46
Cite this article
↗ https://www.doi.org/10.59256/ijrtmr.20240401007References
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Li Jian Wang 1, Yue Cao, Hai Ning Shi
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%20interacts%20with%20small%20molecules%20%28ligands%29.
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24. In VitroAnthelmintic Effects of Medicinal Plants Usedin Czech RepublicJan Urban,1Ladislav Kokoska,2Iva
Langrova,3and Jana Matejkova4. Pharmaceutical Biology2008, Vol. 46, Nos. 10–11, pp. 808–813
25. In vitro anthelmintic activity of Fenugreek seeds extract against Pheritimaposthuma. Chandrashekhar D. Khadse*,
Rajendra B. Kakde, Int. J. Res. Pharm. Sci. Vol-1, Issue-3, 267-269, 2010
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Shaibani/publication/242284043_Anthelmintic_Activity_of_Fumaria_parviflora_Fumariaceae_against_Gastrointestinal_N
ematodes_of_Sheep/links/56afc64108ae9f0ff7b291cd/Anthelmintic-Activity-of-Fumaria-parviflora-Fumariaceae-against-
Gastrointestinal-Nematodes-of-Sheep.pdf
46. https://www.mdpi.com/154464
47.https://www.researchgate.net/profile/Muhammad-Akhtar-
11/publication/237256326_In_Vitro_Inhibitory_Effects_of_Sorghum_bicolor_on_Hatching_and_Moulting_of_Haemonchu
s_contortus_Eggs/links/0f31752fb026a2ec9f000000/In-Vitro-Inhibitory-Effects-of-Sorghum-bicolor-on-Hatching-and-
Moulting-of-Haemonchus-contortus-Eggs.pdf
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nd_In_silico_approach/links/5f953240a6fdccfd7b7d688a/Anthelmintic-activity-of-Mansoa-alliacea-against-Pheretima-
posthuma-In-vitro-and-In-silico-approach.pdf
52. https://www.sciencedirect.com/science/article/pii/S0166685118300860
53. https://fjps.springeropen.com/articles/10.1186/s43094-021-00218-2
54. https://clinphytoscience.springeropen.com/articles/10.1186/s40816-018-0077-8
55. Synthesis, in vitro antioxidant, anthelmintic and molecular docking studies of novel dichloro substituted benzoxazole-triazolo-thione derivatives.
R.V. Satyendra, K.A. Vishnumurthy, H.M. Vagdevi, K.P. Rajesh, H. Manjunatha, A. Shruthi
56. https://pubmed.ncbi.nlm.nih.gov/21453994/
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_l_via_in_silico_molecular_docking_and_in_vivo_extract_application
59. https://www.phytojournal.com/archives/2020/vol9issue1/PartU/9-1-247-509.pdf
60.https://link.springer.com/article/10.1007/s12039-020-1737-z?error=cookies_not_supported&code=9174f961-8433-
4cb7-b8cd-e5c0720c8c9a
61. B. Harithapriyanka, L. Spandana et al. Hypoglycemic and antidiabetic activity of
aqueous extract of leaves of alangiumsalvifolium in alloxan induced diabetic rats.
Journal of Pharmacy Research. 2010; 3(7): pp. 1032.
62. https://pubmed.ncbi.nlm.nih.gov/18673129/
2. Hotez PJ, Brindley PJ, Bethony JM, King CH, Pearce EJ, Jacobson J. Helminth infections: the great neglected tropical diseases. The
Journal of clinical investigation. 2008 Apr:118(4):1311-21. doi: 10.1172/JCI34261. Epub [PubMed PMID: 18382743]
3. Cox FE. History of human parasitology. Clinical microbiology reviews. 2002 Oct:15(4):595-612 [PubMed PMID: 12364371]
4. Jourdan PM, Lamberton PHL, Fenwick A, Addiss DG. Soil-transmitted helminth infections.Lancet (London, England). 2018 Jan
20:391(10117):252-265. doi: 10.1016/S0140-6736(17)31930-X. Epub 2017 Sep 4 [PubMed PMID: 28882382]
5. Novianty S, Dimyati Y, Pasaribu S, Pasaribu AP. Risk Factors for Soil-Transmitted Helminthiasis in Preschool Children Living in
Farmland, North Sumatera, Indonesia. Journal of tropical medicine. 2018:2018():6706413. doi: 10.1155/2018/6706413. Epub 2018 Apr 4
[PubMed PMID: 29849666]
6. Helminths, Soil-Transmitted CDC Yellow Book 2023 Travel-Associated Infections & Diseases. Author(s): Mary Kamb, Sharon
Roy
7. https://www.verywellhealth.com/helminths-5207511
8. World HalthOrganisation: Soil-transmitted helminth infections 18 January 2023
9. https://www.researchgate.net/publication/352899770_Helminthiasis
10. NIH Soil-transmitted helminth infections
Peter Mark Jourdan 1, Poppy H L Lamberton 2, Alan Fenwick 3, David G Addiss 4
11. Helminths: Pathogenesis and Defenses. Derek Wakelin&Samuel Baron
12. Helminth infections and intestinal inflammation
Li Jian Wang 1, Yue Cao, Hai Ning Shi
13. https://www.ncbi.nlm.nih.gov/pubmed/1531789314
14. Drug Discovery Using Chemical Systems Biology: Repositioning the Safe Medicine Comtan to Treat Multi-Drug and
Extensively Drug Resistant Tuberculosis
Sarah L. Kinnings, Nina Liu, Nancy Buchmeier ,Peter J. Tonge, Lei Xie,Philip E. Bourne
15. Roberts E, Magis A, Ortiz JO, Baumeister W, Luthey-Schulten Z. Noise contributions in an inducible genetic switch: a
whole-cell simulation study. PLoSComput Biol. 2011 Mar;7(3):e1002010. doi: 10.1371/journal.pcbi.1002010. Epub 2011
Mar 10.
16. https://mpkb.org/home/patients/assessing_literature/in_vitro_studies
17.https://www.sciencedirect.com/topics/neuroscience/molecular-
docking#:~:text=Molecular%20docking%20is%20the%20study%20of%20how%20two,a%20protein%20%28enzyme%29
%20interacts%20with%20small%20molecules%20%28ligands%29.
18. Frisch, J.D. & Frisch, C.D., Aves Brasileiras e Plantas que as atraem, São Paulo: DalgasEcotec, 2005, 398, ISBN 978-
85-85015-07-7
19.https://plants.ces.ncsu.edu/plants/caesalpinia-pulcherrima/
20.https://pubmed.ncbi.nlm.nih.gov/21572651/
21. Eisenmann D. M. Wnt signaling.WormBook.2005; 1551.
22. H. Rabiu and M. Subhashish. Investigation of invitro anthelmintic activity of Azadirachtaindica leaves. International
Journal of Drug Development and Research. 2011; 3(4): pp. 94 –100.
23. Borkar VS, Gangurde HH, Gulecha VS, Bhoyar PK, Mundada AS. Evaluation of
in vitro anthelmintic activity of leaves of Butea monosperma. International
Journal of Phytomedicine. 2010; 2: pp. 31 – 35.
24. In VitroAnthelmintic Effects of Medicinal Plants Usedin Czech RepublicJan Urban,1Ladislav Kokoska,2Iva
Langrova,3and Jana Matejkova4. Pharmaceutical Biology2008, Vol. 46, Nos. 10–11, pp. 808–813
25. In vitro anthelmintic activity of Fenugreek seeds extract against Pheritimaposthuma. Chandrashekhar D. Khadse*,
Rajendra B. Kakde, Int. J. Res. Pharm. Sci. Vol-1, Issue-3, 267-269, 2010
26. In-vitro anthelmintic activity of Coleus aromaticus root in Indian Adult Earthworm
Author links open overlay panelArshad Hussain, Anuj SKumar Sonkar, Md. Parwez Ahmad, Shadma Wahab
27.https://www.sciencedirect.com/science/article/abs/pii/S0367326X08000269#preview-section-references
28. https://www.mdpi.com/2076-2615/12/19/2718
29.https://www.sciencedirect.com/science/article/abs/pii/S0378874121006218#preview-section-references
30. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973903/
31. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198815/
32. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243676/
33. https://www.mdpi.com/2306-7381/9/3/129
34. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822243/
35. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204145/
36. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557511/
37. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068120/
38. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749317/
39. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265098/
40. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805354/
41. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805354/
42. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805354/
43. https://www.sciencedirect.com/science/article/abs/pii/S0014489407000434
44.https://link.springer.com/article/10.1007/s00436-013-3541-x?error=cookies_not_supported&code=6e17a569-3368-
4e60-87ab-655758ba04fc
45.https://www.researchgate.net/profile/Ibrahim-Al-
Shaibani/publication/242284043_Anthelmintic_Activity_of_Fumaria_parviflora_Fumariaceae_against_Gastrointestinal_N
ematodes_of_Sheep/links/56afc64108ae9f0ff7b291cd/Anthelmintic-Activity-of-Fumaria-parviflora-Fumariaceae-against-
Gastrointestinal-Nematodes-of-Sheep.pdf
46. https://www.mdpi.com/154464
47.https://www.researchgate.net/profile/Muhammad-Akhtar-
11/publication/237256326_In_Vitro_Inhibitory_Effects_of_Sorghum_bicolor_on_Hatching_and_Moulting_of_Haemonchu
s_contortus_Eggs/links/0f31752fb026a2ec9f000000/In-Vitro-Inhibitory-Effects-of-Sorghum-bicolor-on-Hatching-and-
Moulting-of-Haemonchus-contortus-Eggs.pdf
48. https://ecommons.aku.edu/pakistan_fhs_mc_bbs/242/
49. https://www.sciencedirect.com/science/article/pii/S0378874105004125
50. https://www.sciencedirect.com/science/article/pii/S030440170800607
51.https://www.researchgate.net/profile/PrasanthDintakurthi/publication/344869136_Anthelmintic_activity_of_Mansoa_alliacea_against_Pheretima_posthuma_In_vitro_a
nd_In_silico_approach/links/5f953240a6fdccfd7b7d688a/Anthelmintic-activity-of-Mansoa-alliacea-against-Pheretima-
posthuma-In-vitro-and-In-silico-approach.pdf
52. https://www.sciencedirect.com/science/article/pii/S0166685118300860
53. https://fjps.springeropen.com/articles/10.1186/s43094-021-00218-2
54. https://clinphytoscience.springeropen.com/articles/10.1186/s40816-018-0077-8
55. Synthesis, in vitro antioxidant, anthelmintic and molecular docking studies of novel dichloro substituted benzoxazole-triazolo-thione derivatives.
R.V. Satyendra, K.A. Vishnumurthy, H.M. Vagdevi, K.P. Rajesh, H. Manjunatha, A. Shruthi
56. https://pubmed.ncbi.nlm.nih.gov/21453994/
57. https://clinphytoscience.springeropen.com/counter/pdf/10.1186/s40816-018-0077-8.pdf
58.https://www.researchgate.net/publication/364189953_Discovery_of_new_herbal_anthelmintics_from_artemisia_annua
_l_via_in_silico_molecular_docking_and_in_vivo_extract_application
59. https://www.phytojournal.com/archives/2020/vol9issue1/PartU/9-1-247-509.pdf
60.https://link.springer.com/article/10.1007/s12039-020-1737-z?error=cookies_not_supported&code=9174f961-8433-
4cb7-b8cd-e5c0720c8c9a
61. B. Harithapriyanka, L. Spandana et al. Hypoglycemic and antidiabetic activity of
aqueous extract of leaves of alangiumsalvifolium in alloxan induced diabetic rats.
Journal of Pharmacy Research. 2010; 3(7): pp. 1032.
62. https://pubmed.ncbi.nlm.nih.gov/18673129/
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