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Earthquakes plays an important part in the analysis and designing of structure. It takes long time to analyse and design structure manually under different loading conditions but with the help of software the analysis and construction of any structure can be done easily so with the help of STAAD PRO software we Compare the performance of Diagrid Structural Building and conventional structural buildings with plan irregularities to analyze the stability of structure in seismic zone .Buildings with large height are more vulnerable to collapse due to high wind and earthquake load. The risk of failure in such a multistory building can be minimized by adopting lateral load resisting systems. In this study, modeling is done on irregular plan. For irregular plan, C-shape of plan and L-Shape of plan are considered. In this thesis, four models are analyzed, two diagrid frames, and two conventional frame models for C-Plan and L-Plan separately. The building consists twelve storey frame structure having total height 36m and storey height is kept 3 m for each floor. In this project the First Comparison done between diagrid structural system, and conventional frame structural system for C-Type and L-Plan separately and after that second overall comparison is between C-Plan and L- plan. Comparison has been done for different types of models for earthquake load case by considering various parameters like, displacement, base shear, bending moment. STADD PRO stands for structural analysis and design software.M40 grade of concrete and Fe-500 steel as per IS 800:2007 were used. Load combinations are taken as per IS 1893:2002 code and method of analysis used is Linear response method and live load are taken according to IS-875. Earthquake zone 4 has been adopted for analysis. When diagrid are connected to the floor the fluctuations of results occurred between the floor. The value of Base shear in diagrid structure is smaller than the bare frames. The result of work showed that diagrid system resist lateral load more efficiently than conventional frame as it yields the least value for displacement, bending moment and shear force