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Case Study
Patterns and Clinical Outcomes of Immediate Hypersensitivity Reactions to Ceftriaxone: A Case Series Study
Dr. T. Rengaraj1
Jayasri Karthikesan2
Haripriya Gurumoorthy3
Atchayavarshini Rameshkumar4
Deepasree Balathandayuthapani5
Surya Rajendran,Naveenkumar Manikandan6
1 Department of Medicine, Government Medical College and Hospital, Nagapattinam, Tamil Nadu, India 2 3 4 5 6 Department of Pharmacy practice, EGS Pillay College of Pharmacy MoU with GMCH, Nagapattinam, Tamil Nadu, India
Published Online: September-October 2025
Pages: 99-103
Cite this article
↗ https://www.doi.org/10.59256/ijrtmr.20250505016References
1. Pichichero ME. Cephalosporins can be prescribed safely in penicillin-allergic patients. J Fam Pract.2006;55(7):583–587.
2. Romano A, et al. Hypersensitivity reactions to beta-lactams. Curr Opin Allergy Clin Immunol. 2004;4(4):271–276.
3. Solensky R. Allergy to beta-lactam antibiotics. J Allergy Clin Immunol. 2012;130(6):1442–1448.
4. Khan DA, Solensky R. Drug allergy. J Allergy Clin Immunol. 2010;125(2 Suppl 2):S126–S137.
5. Macy E, Ngor EW. Safely administering cephalosporins to penicillin-allergic patients. J Allergy Clin Immunol Pract. 2013;1(3):258–263.
6. Park H, et al. Cross-reactivity of beta-lactams in immediate hypersensitivity. Allergy Asthma Immunol Res.2012;4(2):86–90.
7. Torres MJ, et al. Diagnosis of immediate allergic reactions to beta-lactams. Curr Allergy Asthma Rep.2011;11(1):17–23.
8. Garvey LH, et al. Immediate hypersensitivity reactions to antibiotics. Curr Opin Allergy Clin Immunol.2006;6(4):296–302.
9. Pharmacovigilance Programme of India (PvPI). Guidelines for adverse drug reaction reporting. CDSCO, India.
10. Naranjo CA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther.1981;30(2):239–245.
11. Shalviri G, et al. Adverse drug reactions of ceftriaxone: a prospective study. Int J Clin Pharmacol Ther. 2012;50(9):643–648.
12. Lacroix C, et al. Neurological adverse effects of antibiotics: a review. Front Pharmacol. 2021;12:660.
13. Medscape. Ceftriaxone Drug Information. Available from: https://reference.medscape.com/drug/ceftriaxone-342510
14. Trubiano JA et al., Clin Infect Dis, 2017;65:219–226.
15. Pichichero ME, J Clin Pharmacol, 2006;46:1133–1141.
16. Macy E, Ann Allergy Asthma Immunol, 2014;112:197–204
17. Simons FE et al., J Allergy Clin Immunol, 2011;127:e1–e8.
2. Romano A, et al. Hypersensitivity reactions to beta-lactams. Curr Opin Allergy Clin Immunol. 2004;4(4):271–276.
3. Solensky R. Allergy to beta-lactam antibiotics. J Allergy Clin Immunol. 2012;130(6):1442–1448.
4. Khan DA, Solensky R. Drug allergy. J Allergy Clin Immunol. 2010;125(2 Suppl 2):S126–S137.
5. Macy E, Ngor EW. Safely administering cephalosporins to penicillin-allergic patients. J Allergy Clin Immunol Pract. 2013;1(3):258–263.
6. Park H, et al. Cross-reactivity of beta-lactams in immediate hypersensitivity. Allergy Asthma Immunol Res.2012;4(2):86–90.
7. Torres MJ, et al. Diagnosis of immediate allergic reactions to beta-lactams. Curr Allergy Asthma Rep.2011;11(1):17–23.
8. Garvey LH, et al. Immediate hypersensitivity reactions to antibiotics. Curr Opin Allergy Clin Immunol.2006;6(4):296–302.
9. Pharmacovigilance Programme of India (PvPI). Guidelines for adverse drug reaction reporting. CDSCO, India.
10. Naranjo CA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther.1981;30(2):239–245.
11. Shalviri G, et al. Adverse drug reactions of ceftriaxone: a prospective study. Int J Clin Pharmacol Ther. 2012;50(9):643–648.
12. Lacroix C, et al. Neurological adverse effects of antibiotics: a review. Front Pharmacol. 2021;12:660.
13. Medscape. Ceftriaxone Drug Information. Available from: https://reference.medscape.com/drug/ceftriaxone-342510
14. Trubiano JA et al., Clin Infect Dis, 2017;65:219–226.
15. Pichichero ME, J Clin Pharmacol, 2006;46:1133–1141.
16. Macy E, Ann Allergy Asthma Immunol, 2014;112:197–204
17. Simons FE et al., J Allergy Clin Immunol, 2011;127:e1–e8.
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